When he came to America, his dream to become a priest was aroused in his soul but he didn't have the necessary education. His brother also wanted to become a priest ~ and that's when Msgr. Kelly stepped in to help both of the boys achieve their calling. They both were called to the Order of the Holy Cross and began their studies at Catholic University in Washington, DC. Patrick contracted TB and was ailing for about a year at the Notre Dame infirmary. It was at this time that Rev. Cornelius Hagerty, CSC told him to pray to Our Lady, with great faith. Patrick prayed a rosary novena and at the completion of the novena, proclaimed that the was cured through Our Lady's intercession. And he was!! and the doctors finally confirmed the miraculous healing.
Together, the boys were both ordained as priests of the Holy Cross on June 15, 1941. To thank Our Lady for this great grace of the priesthood and of the healing, Fr. Peyton dedicated his life to spreading the practice of the family rosary. He embarked on his missionary call and traveled around the world hosting Rosary Rallies. He always preached about the rosary and drew people to a closer relationship with the Blessed Mother. He preceded Bishop Sheen is harnessing the power of the media, producing over 600 TV and radio shows and mingled with celebrities.